Targeted therapy
Targeted therapies are drugs used to treat some cancers. They target specific molecules in the cancer cells that control how these cells grow and multiply.
Targeted therapy can be used to treat certain neuroendocrine tumours. They are only funded for particular types of NETs and particular situations
What you need to know
What is targeted therapy?
Targeted therapy affects specific molecules involved in cancer growth. These are known as molecular targets.
Most molecular targets are genes or proteins. They can be located inside or on the surface of cancer cells, or in the area around the cancer.
There are several types of targeted therapy that act in different ways, including:
- blocking the chemicals that tell cells to grow
- stopping blood flow to the cancer
- changing the way cancer cells work and causing them to die
- delivering toxins directly into the cancer cells.
Targeted therapy may be used alone or in combination with other treatments.
Will targeted therapy work for me?
Targeted therapies are only suitable for some cancers because not all cancers have molecular targets.
Targeted therapies also work better for some people than for others. This is because not all cancers with targets respond to treatment with a targeted therapy. Sometimes the cancer will stop growing or get smaller, and sometimes there will be no response.
Your doctor may send a sample of your cancer to be tested for possible targets. If a target is present you may be able to have treatment with a targeted therapy. Different cancers can have different molecular targets, which are treated with different targeted therapies.
Targeted therapy for neuroendocrine tumours
Some people with advanced NETs may be treated with targeted therapy.
It can be given:
- when the NET has spread from where it started
- if surgery is not recommended
- if the NET doesn’t respond to other treatments
- to slow growth of the NET.
Some targeted therapies are currently used to treat certain advanced NETs. These are taken orally as capsules or tablets. Other targeted therapies may be available in clinical trials.
They are only funded for particular types of NETs and particular situations.
Other resources we recommend
What to ask or talk about
Side effects of targeted therapies used to treat NETs
Traditional chemotherapy drugs affect cells that are dividing quickly. This includes many normal cells as well as cancer cells.
Targeted therapies only affect certain types of cells, so they do not affect as many normal cells as chemotherapy drugs. This means that the side effects they cause are not like those caused by chemotherapy.
The side effects of targeted therapies that are used to treat NETs depend on which targeted therapy you are given but also vary from one person to another.
Some possible side effects of targeted therapies used in NETs are listed below:
- nausea and vomiting
- low blood counts and risk of infection
- bleeding or blood clots
- mouth ulcers or sores
- diarrhoea
- tiredness (fatigue)
- skin rash that looks like acne
- lung problems
- muscle, bone and joint pain
- sensitivity to sunlight – dry, red or itchy skin
- tenderness and blistering of the palms and soles (hand-foot syndrome)
- high blood pressure
- slow wound healing
- changes to the way the heart works
- hair thinning
- nail changes.
Ask your doctor, nurse or pharmacist what side effects to expect, and how to manage them.
Checklists
Other resources we recommend
Next steps
Preparing for targeted therapy
Before starting a targeted therapy you may need to sign a consent form. It is important to understand what you are consenting to.
Some other important things you should know are:
- whether you need any tests before your treatment
- whether you need to change your diet or medications
- if you need to take any premedication (tablets you take before your treatment)
- how you will have your treatment, e.g. as a tablet or in a drip
- whether you need to take some time off work
- if you can drive or catch public transport after treatment.
You may need medicines to manage side effects. It is best to get these before you start treatment, and know what they are for and how to take them. You should also have a thermometer and know how to use it.
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NeuroEndocrine Cancer Australia1399 287 363
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Cancer Council Mon-Fri 9am-5pm13 11 20
