Primary content

Authors

J Kipritidis (Lead)

F Hegi-Johnson

E Eslick

J Barber

A Shieh

P Keall

Aims

To perform the first cross-modality correlation study of pulmonary function changes between daily CT ventilation images, nuclear medicine imaging and spirometry.

Method

Lung cancer patients received daily CT imaging as part of image guided radiotherapy treatment at Nepean Cancer Care Centre. Ventilation images (VIs) were generated using in-house software to measure regional lung volume changes within the respiratory cycle, a surrogate for ventilation. Daily ventilation changes were quantified, with VIs correlated against pre- and post-treatment nuclear medicine functional lung imaging.

Results

CT ventilation imaging is capable of achieving good similarity with `gold standard’ nuclear medicine functional lung imaging, with pixel-to-pixel correlations as high as 0.6 in some patients. A cross modality analysis of functional changes is underway and we are investigating the potential for CT image enhancement to improve the accuracy and sensitivity of this technique.

Implications

CT-based ventilation imaging is potentially useful for imaging pulmonary function in lung cancer radiotherapy patients. Once optimised and validated, CT-based ventilation imaging will give clinicians a powerful, cost-effective and highly accessible new tool to measure, predict and minimise the side effects of lung cancer radiotherapy treatment.