Somatostatin analogues
Somatostatin analogues are drugs that help to control symptoms caused by some NETs, particularly those that cause carcinoid syndrome.
What are somatostatin analogues?
Somatostatin is a hormone made by the body. It controls the release of other hormones, including the ones that control the emptying of the stomach and bowel.
Somatostatin analogues are medications that are like our body’s natural somatostatin.
They can be used:
- to reduce down the amount of hormones made and released by some NETs
- to slow down the growth of a NET that is advanced or has metastasised.
Somatostatin analogues are particularly useful for NETs which make excessive amounts of hormones that cause a group of symptoms known as carcinoid syndrome. These symptoms include:
- diarrhoea
- facial flushing
- wheezing
- shortness of breath
- heart problems.
Somatostatin analogues can be given:
- as an injection under the skin (subcutaneous)
- as an injection into a muscle (intramuscular).
Side effects of somatostatin analogues
Side effects of somatostatin analogues may include:
- nausea and vomiting
- bloating and wind
- headache
- redness and swelling at the injection site
- changes to how the bowel works – diarrhoea or constipation
- abdominal pain
- gallstones
- slow heart rate
- high blood sugar – thirsty, urinary frequency, repeated infections.
For more specific information about what side effects to expect and how to manage them:
- talk to your doctor, nurse or pharmacist about side effects
- see our information about managing side effects.
Make sure you know who to contact and on what number if you have any concerns or become unwell.
Other resources we recommend
Use the following links to find out more about this topic.
Somatostatin analogues (SSA) information
https://neuroendocrine.org.au/wp-content/uploads/2020/07/N5058-NECA_SSAInfo_Download-v1.pdf
Patient information – Octreotide
https://www.eviq.org.au/medical-oncology/upper-gastrointestinal/neuroendocrine/706-neuroendocrine-advanced-octreotide-sandostati/patient-information#side-effects
Patient information – Lanreotide
https://www.eviq.org.au/medical-oncology/upper-gastrointestinal/neuroendocrine/3841-neuroendocrine-advanced-lanreotide-somatulin/patient-information#side-effects
What are somatostatin analogues?
https://www.cancerresearchuk.org/about-cancer/neuroendocrine-tumours-nets/treatment/somatostatin-analogues/what-are
Drug therapy for neuroendocrine tumours (NETs)
https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/treatment/drug-therapy
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